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Images from organ systems: Skin to Urinary Tract
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Histopathology
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Wound healing. The biology of healing (fibroplasia) is begun by tissue injury characterized by microvascular damage resulting in extravasation into the injury site. Vasoactive amines, other cell mediators, and various cytokines are released by inflammatory cells and contribute to the healing process.
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132 |
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Skin
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Basal cell carcinoma (BCC, basal cell epithelioma, basalioma, or rodent ulcer). BCC has numerous growth patterns including the most characteristic insular. Solid basaloid islands of fused, cystic, or solid architecture are noted. These are usually bordered by a palisaded outer row of cells. |
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127 |
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Skin
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Squamous cell carcinoma (SCC). Tumors denote a range of atypical squamous cells grown past the in situ phase and invasive into the dermis or beyond. Histologic patterns consist of lobules of squamous cells forming microcavities filled with parakeratotic keratin with marked cellular pleomorphism. |
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116 |
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Skin
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Malignant melanoma. The lesion has already gone through the first or macular stage parallel to the dermis. This is the nodular phase of MM extending in all directions into the dermis. Diagnosis of MM depends on the identification of atypical melanocytes, as seen in the upper left corner. |
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66 |
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Skin
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Kaposi’s sarcoma (KS). Geographic distribution and epidemiologic evidence points to KS as an opportunistic infection caused by human herpesvirus 8 (HHV-8) or Kaposi’s sarcoma-associated virus (KSHV) as the etiologic agent. KS is a common neoplasm associated with HIV/AIDS and also found in many other visceral areas. |
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75 |
| Urinary tract |
Normal glomerular microanatomy. Bowman’s capsule contains a tuft of interconnected capillaries with a central mesangium, an irregular support structure containing cells and matrix material. Capillaries are lined with visceral endothelial cells containing a basement membrane. |
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115 |
| Urinary tract |
Diabetic kidney (nephropathy stages 2 & 3) showing microangiopathy, arteriosclerosis, glomerular basement membrane (GBM) thickening, increased mesangial cells and matrix, but no significant glomerulosclerosis. |
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69 |
| Urinary tract |
Diabetic kidney (nephropathy stages 4 & 5) showing advanced glomerulosclerosis hallmarked by the presence of segmented acellular nodules (Kimmelsteil-Wilson lesions), thickened glomerular basement membrane (GBM), arteriosclerosis, and microangiopathy. |
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59 |
| Urinary tract |
Renal cell carcinoma (RCC). |
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87 |
